NBD-556 tisone InChi: InChI=1S/C16H22O3/c1-11-8-12(10-16(2

InChi: InChI=1S/C16H22O3/c1-11-8-12(10-16(2

Planta Med

290(22):13641-53

Smiles: CN1C(=NC2=CC=CC=C12)C1C=C2C(N=C(CCC)N2CC2=CC=C(C=C2)C2=CC=CC=C2C(O)=O)=C(C)C=1

3-oxazol-2-yl)(H)propanoic acid

NBD-556 tisone InChi: InChI=1S/C16H22O3/c1-11-8-12(10-16(2NBD 556 is a HIV 1 entry inhibitor. NBD 556 inhibited cellcell fusion between H9 HIV 1IIIB and MT 2 (IC50 ~3 M). NBD 556 prevent gp120 binding to CD4. The HIV 1 entry into host cells is a complex, multi factors involved, and multi step process. Especially, the attachment of HIV 1 envelope glycoprotein gp120 to the host cell receptor CD4 is the first key step during entry process, representing a promising antiviral therapeutic target. Product