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152(5):834-41
CAS Number: 366789-02-8
Molecular Weight: 282
robust PK/PD correlation and tumor growth inhibition (TGI) in a U87MG mouse xenograft model
10(7):681-4
Sertraline Hydrochloride IN-1 152(5):834-41Sertraline, also known as , is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2. 8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake
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