CASIN - Cdc42 Inhibitor. CAS# 425399-05-9 size:2 mg solid and HDAC6 in cell-free assays

and HDAC6 in cell-free assays

specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1)

InChiKey: SPTWXRJNCFIDRQ-ZHACJKMWSA-N

Molecular Weight: 332

controlling SHP2 activity is of significant therapeutic interest

CASIN - Cdc42 Inhibitor. CAS# 425399-05-9 size:2 mg solid and HDAC6 in cell-free assaysCASIN, CAS No. 425399 05 9, is a novel and potent Cdc42 inhibitor with an IC50 ~2 M. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and