Pay in 4 interest-free payments of $32.25 Learn more
Ships within 48 hours · Estimated delivery Jul 26 - Jul 31
GSK-5959 (3a) also displays selectivity over the closely related family members
(2012) Nature Reviews Drug Discovery 11
Solubility: DMSO up to 10 mM
4-dihydro-1H-isoquinolin-2-yl]methanone
CAS Number: 183322-45-4
N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 GSK-5959 (3a) also displays selectivityN106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart
US$ 54.95
US$ 13.18
US$ 54.99