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CFTR Inh172
It displays >17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested
albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus
Yoshizawa S
MK-8776 S-isomer induces accumulation of γ-H2AX within 2 hours
BMS-309403 Catalog No.:M20293-C CFTR Inh172BMS 309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS 309403 interacts with the fatty acid binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS 309403 improves endothelial function in apolipoprotein E deficient mice and in cultured human
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