![NB-598 Hydrochloride alafenamide hemifumarate Smiles: COC1C=C(C[C@@H]2[C@@H](CC3C=C(OC)C(=CC=3)OC)COC2=O)C=CC=1O](https://cdn.shopify.com/s/files/1/0389/1897/9723/files/1690524027259_1.png?v=1690524045)
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Smiles: COC1C=C(C[C@@H]2[C@@H](CC3C=C(OC)C(=CC=3)OC)COC2=O)C=CC=1O
2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid sodium
H2O/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21
Chemical Name: N-[(2S)-1-amino-3-(3
Smiles: O=C(NC1=NC=C(CCNC2=NC=NC3C=CSC=32)S1)NC1=CC(Cl)=CC=C1
NB-598 Hydrochloride alafenamide hemifumarate Smiles: COC1C=C(C[C@@H]2[C@@H](CC3C=C(OC)C(=CC=3)OC)COC2=O)C=CC=1ONB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.