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and USP7 exerts both p53-dependent and p53-independent effects on controlling cell proliferation and apoptosis
significantly extends survival in a mouse model of FLT3-ITD AML at doses as low as 1 mg/kg when dosed orally once a day
Formula: C17H15FN2O3
and HDAC3 (58 nM
InChiKey: YEVOZZZLKJKCCD-UHFFFAOYSA-N
Daminozide - KDM2/7 Histone Demethylases Inhibitor. CAS# 1596-84-5 size:10 mg solid and USP7 exerts both p53-dependentDaminozide, CAS No. 1596 84 5, is a potent and selective small molecule inhibitor of the KDM2 7 family of human JmjC histone demethylases. It inhibits KDM2A at IC50 ~1. 5 M, PHF8 at IC50 ~0. 55 M, and KIAA1718 at IC50 ~2. 1 M. It has at least 60 fold selectivity as an inhibitor of the KDM2 7 subfamily over the other demethylase subfamily members such as KDM3A, KDM4E, KDM5C and KDM6B, and exhibits no inhibition even at 1 mM for PHD2, FIH, and BBOX1
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