7α-Hydroxy-4-cholesten-3-one Catalog No.:M26243-C PF-5274857 was found to effectively

PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice

Derazantinib inhibits FGFR1 and FGFR2 mutants associated with craniosynostoses

and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days

Chemical Name: tert-butyl N-(17-hydroxy-3

Chemical Name: (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-[(carboxymethyl)carbamoyl]-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid

7α-Hydroxy-4-cholesten-3-one Catalog No.:M26243-C PF-5274857 was found to effectively7 Hydroxy 4 cholesten 3 one is an intermediate in synthesis of bile acids from cholesterol. 7 Hydroxy 4 cholesten 3 one is a pregnane X receptor (PXR) agonist. 7 Hydroxy cholest 4 en 3 one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7 Hydroxy cholest 4 en 3 one is the physiological substrate for CYP8B1. Product information CAS Number: 3862 25 7 Molecular Weight: 400.