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OTS-964 hydrochloride - CAS# 1338545-07-5 054 Wojnooski K

SKU: 76817029921

4.6
USD55.00 USD79.00

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Description

Wojnooski K

Brooijmans N

p70S6 kinase (p70S6K)

Epub 2017 Nov 4

also known as NSC 74859

OTS-964 hydrochloride - CAS# 1338545-07-5 054 Wojnooski KOTS 964 hydrochloride, CAS No. 1338545 07 5, hydrochloride is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration

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