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CAS Number: 2136247-12-4
6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2
65(5):435-44
12 cells (EC50 ~ 4 nM) and RS4
InChiKey: HRDUUSCYRPOMSO-ROUUACIJSA-N
Capmatinib HCl hydrate - CAS# 1865733-40-9 Laurdan CAS Number: 2136247-12-4Capmatinib HCl hydrate, CAS No. 1865733 40 9, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto oncogene c Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c Met inhibitor INC280 selectively binds to c Met, thereby inhibiting c Met phosphorylation and disrupting c Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c Met protein or
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