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GNF4877 and its analog GNF7156 are the good chemical tools to support the feasibility of treating diabetes with an oral therapy to restore β-cell mass
(1998) Bioorg Med Chem Lett
(2008) Biochem J
AK-7 was used at 10-25 µM in vitro and in cellular assays
inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects
CHIR99021 - GSK3β Inhibitor. CAS# 252917-06-9 Catalog No.:M60002-25S GNF4877 and its analog GNF7156CHIR99021, CAS No. 252917 06 9, is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3 (GSK3) with an IC50 ~7 nM. It can effectively activate Wnt signaling pathway in various cellular systems. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of embryonic stem cells and tissue specific adult stem cells (such as hematopoietic stem and progenitor
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