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BMS-477118
InChi: InChI=1S/C24H28N2O3/c1-23(2
Smiles: CC1(C)C2CC(O)C3=C(C(=O)CC4(C)C(CC(O)C43C)C(C)CCC(O)=O)C2(C)CCC1=O
InChi: InChI=1S/C23H18N2O2/c26-22(23(27)24-18-11-5-2-6-12-18)20-16-25(15-17-9-3-1-4-10-17)21-14-8-7-13-19(20)21/h1-14
23(41)16-51-36(46)39(3)10-9-38-2)14-19-26(22)32(45)28-27(30(19)43)29(42)18-7-6-8-21(48-4)25(18)31(28)44/h6-8
Phrixotoxin 3 TFA Catalog No.:M17683-C BMS-477118Phrixotoxin 3 TFA is a potent blocker of voltage gated sodium channels, with IC50s of 0. 6, 42, 72, 288, 610 nM for NaV1. 2, NaV1. 3, NaV1. 4, NaV1. 1 and NaV1. 5, respectively. Phrixotoxin 3 TFA modulates voltage gated sodium channels with properties similar to those of typical gating modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current. Product information Molecular
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