GGTI-2418 14533 InChi: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17

InChi: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17

suggesting that it can be an attractive alternative for potential clinical use

2017 Mar 22

Formula: C5H8O2

Pre-incubation of the H9c2 cells with various concentrations of tBHQ for 24 hours enhances cell viability which is decreased due to exposure to ethanol in a dose-dependent manner

GGTI-2418 14533 InChi: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17GGTI 2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI 2418 inhibits GGTase I and FTase activities with IC50s of 9. 5 nM and 53 M, respectively. GGTI 2418 also increases p27(Kip1) and induces significant regression of breast tumors. Product information CAS Number: 501010 06 6 Molecular Weight: 441. 52 Formula: C23H31N5O4 Chemical Name: (2S) 2 {[(2S) 2 benzyl 4 [(5 methyl 1H imidazol 4 yl)methyl]