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even at concentrations 500 times higher than their IC50 values against gastric H+
2018 Mar 8
Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction
Chemical Name: 4-{6-[6-(4-methylpiperazin-1-yl)-1H-1
dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine
SD-36 Catalog No.:M13867-2 even at concentrations 500 timesSD 36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD 36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD 36 exerts robust anti tumor activity, and achieves complete and long lasting tumor regression in mouse tumor models. SD 36 is composed of the STAT3 inhibitor SI 109, a linker, and an analog of
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