HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Smiles: CN(CC1=CC2=NC(=NC(=C2S1)N1CCOCC1)C1=CN=C(C=C1)OC)C1N=CC(=CN=1)C(=O)NO

Smiles: CN(CC1=CC2=NC(=NC(=C2S1)N1CCOCC1)C1=CN=C(C=C1)OC)C1N=CC(=CN=1)C(=O)NO

is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM

and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism

InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10

347174-05-4

HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Smiles: CN(CC1=CC2=NC(=NC(=C2S1)N1CCOCC1)C1=CN=C(C=C1)OC)C1N=CC(=CN=1)C(=O)NOHIF C2, CAS No. 1422955 31 4, is a potent and selective allosteric inhibitor of hypoxia inducible factor 2 (HIF 2). It binds within the internal cavity of HIF 2 PAS B (Kd of 81 nM) and disrupts heterodimerization of the full length HIF 2 transcription factor. HIF C2 functions effectively as a HIF 2 inhibitor in living cells, disrupting HIF 2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF C2 is selective for the HIF 2