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InChiKey: NRDKOXSXHXTKHR-UHFFFAOYSA-N
Target: dopamine D2 receptor
In vitro kinase assays reveal that CHIR99021 specifically inhibits GSK3β (IC50=~5 nM) and GSK3α (IC50=~10 nM)
1-7H3/t28-
217 and 451 nM for c-Fms
CPI-1189 Catalog No.:M23038-C InChiKey: NRDKOXSXHXTKHR-UHFFFAOYSA-NCPI 1189 is a proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor. AIDS dementia complex is characterized by increased gliosis, apoptosis, and oxidative stress in the CNS, as well as a compromised blood brain barrier. TNF alpha has been reported to be elevated in AIDS dementia complex brains and may contribute to AIDS dementia complex. In vitro: CPI 1189 could potently inhibit p38 MAPK phosphorylation displaying protective action against
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