![SB-705498 - CAS# 501951-42-4 ine (hydrochloride monohydrate) Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10538_1621562050.gif?v=1742881489)
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Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
3-1-2-4/h2*3H
PubMed Central PMCID: PMC4201083
CAS Number: 1001264-89-6
This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies
SB-705498 - CAS# 501951-42-4 ine (hydrochloride monohydrate) Chemical Name: 1-({4-[2-(azepan-1-yl)ethoxy]phenyl}methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-olSB 705498 is an orally bioavailable, competitive antagonist of the capsaicin mediated activation of TRPV1 receptors (pKis = 7. 6, 7. 5, and 7. 3 for human, rat, and guinea pig, respectively). SB 705498 inhibits the capsaicin , acid , and heat mediated activation of the receptor. SB 705498 was shown to be a potent competitive antagonist of the capsaicin mediated activation of the human TRPV1 receptor (pK(i) = 7. 6) with activity at rat (pK(i) = 7. 5)
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