Sunitinib Malate Size:Solid 2 mg RN486 not only potently and

RN486 not only potently and selectively inhibited the Btk enzyme

Formula: C27H30F3N9O

Chemical Name: (2R)-1-{4-[(2R

and inhibits the production of interleukin-1 (IL-1)

5-dimethyloxan-2-yl]-3'-methyl-[2

Sunitinib Malate Size:Solid 2 mg RN486 not only potently andSunitinib, also known as SU11248, is the orally bioavailable malate salt of an indolinone based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet derived