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competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor
p300 and CBP are transcriptional co-activators that modulate DNA replication
[Epub ahead of print] PubMed PMID: 20502937
InChiKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N
tumor growth inhibition (TGI)=74%
Ku-55933 - CAS# 587871-26-9 0193 competitive and cell permeable prolylKU 55933, CAS No. 587871 26 9, is an ATM inhibitor. KU 55933 blocks the phosphorylation of Akt induced by insulin and insulin like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU 55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU 55933 treatment during