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58 μM achieved at 1
Smiles: [2H]C1=C(C#N)C([2H])=C([2H])C(NC2=NC(OC3C(C)=CC(=CC=3C)C#N)=C(Br)C(N)=N2)=C1[2H]
2014 Feb 10
PPAR-α activation reduced LPS-induced inflammation in alveolar epithelial cells
Molecular Weight: 714
(S, R, S)-AHPC-Me dihydrochloride 0275 58 μM achieved at 1(S,R,S) AHPC Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S) AHPC based VHL ligand used in the recruitment of the von Hippel Lindau (VHL) protein. (S,R,S) AHPC Me dihydrochloride can be used to synthesize ARV 771, a von Hippel Landau (VHL) E3 ligase based BET PROTAC degrader. ARV 771 potently degrades BET protein in castration resistant prostate cancer (CRPC) cells with a DC50 <1 nM. Product information Molecular Weight: 517. 51
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