K 01-162 nocitrin 2-b]pyridin-2-yl}-5-methoxy-N

2-b]pyridin-2-yl}-5-methoxy-N

CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells

RET V804M-IN-1 (compound 5) exhibits 3

its antitumor effect is similar to that of 5-Fluorouracil

2013 Aug 9

K 01-162 nocitrin 2-b]pyridin-2-yl}-5-methoxy-NK 01 162 (K162) binds and destabilizes AO ( amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50) Target: Amyloid in vitro: The active drug candidate K162 (EC50 = 0. 080 M), stabilizes hydrophobic core I of A42 peptide (residues 17 21) to its helical conformation by interacting specifically in this region. K01 162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 M. in vivoK01 162 can reduce the brain amyloid