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BAY-985 Catalog No.:M7451-2 NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N

SKU: 90518873496

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Description

NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N

NMS-873 activated the unfolded protein response

Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

Inhibition of PAI-1 via PAI-039 improves dermal wound closure in diabetes mellitus

WO 2010022355 A1 20100225

BAY-985 Catalog No.:M7451-2 NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=NBAY 985 is a potent and highly selective TBK1 IKK inhibitor. BAY 985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKK(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK MEL 2 cells (IC50 = 900 nM). Product information CAS Number: 2409479 29 2 Molecular Weight: 553. 58 Formula: C27H30F3N9O Chemical Name: 1 (4 {(1R) 1 [2 ({6 [6

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