Nav1.7-IN-2 o-dihydrosphingosine GL0388 shows antiproliferative activities against

GL0388 shows antiproliferative activities against various cancer cells

a potent and selective

and a bitter

2 days and 5 days) inhibits growth of U373MG astroeytes

72 hours) potently inhibit tumorigenic murine macrophage cell line M5076 cellular proliferation

Nav1.7-IN-2 o-dihydrosphingosine GL0388 shows antiproliferative activities againstNav1. 7 IN 2 is an inhibitor of voltage gated sodium channels (Nav), in particular Nav 1. 7, with IC50 of 80 nM. IC50 value: 80 nMTarget: Nav 1. 7Nav1. 7 IN 2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1. 7 IN 2 is a Nav1. 7 channel inhibitor extracted from patent WO 2011103196 A1, compound example J, has an