SAR-020106 22279 442 (2002) 163-171

442 (2002) 163-171

InChiKey: JMTNHBQFZOWQKE-IQWMDFIBSA-N

This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis

Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0

for human recombinant receptors)

SAR-020106 22279 442 (2002) 163-171SAR 020106 is an ATP competitive, potent, and selective CHK1 inhibitor with an IC50 of 13. 3 nM for human CHK1. SAR 020106 shows excellent selectivity over CHK2. SAR 020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3 to 29 fold in several colon tumor lines and in a p53 dependent fashion. SAR 020106 can enhance antitumor activity with selected anticancer drugs. Product information CAS Number: 1184843 57 9 Molecular Weight: 382.