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R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity
InChi: InChI=1S/C31H34O14/c1-28-13-30(38)20-11-31(28
Meys which possesses anti-cancer activity
Mifamurtide TFA acts as a nonspecific immunomodulator by activating macrophages and monocytes related to the upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines including tumor necrosis factor (TNF)-a
Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs)
EN6 HIBO R547 is orally bioavailable diaminopyrimidineEN6 is a small molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v ATPase). EN6 mediated ATP6V1A modification decouples the v ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP 43 aggregates, a causative agent in frontotemporal dementia, in a lysosome dependent manner.
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