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small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha
Smiles: C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3C(=O)C4C(=CC(O)=CC=4O)OC=3C3C=CC(O)=CC=3)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
InChiKey: WHQCHUCQKNIQEC-UHFFFAOYSA-N
InChiKey: VQAYFKKCNSOZKM-IOSLPCCCSA-N
InChi: InChI=1S/C28H38N8O5/c1-20-19-35(14-17-41-20)28(38)30-22-9-7-21(8-10-22)25-31-26(34-12-15-40-16-13-34)23-18-29-36(27(23)32-25)11-5-3-2-4-6-24(37)33-39/h7-10
Vps34-IN-2 - CAS# 1523404-29-6 ide-Piperazine-PEG3-COOH small molecule inhibitor of hypoxiaVps34 IN 2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP FYVE cellular assay, respectively. Vps34 IN 2 shows antiviral activity against SARS CoV 2 (IC50 of 3. 1 M), HCoV 229E (IC50 of 0. 7 M) and HCoV OC43. Product information CAS Number: 1523404 29 6 Molecular Weight: 402. 41 Formula: C18H25F3N4O3 Chemical Name: (S) 9 (3 methyl 2 oxobutyl) 2 ((R) 3 methylmorpholino) 8