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Epub 2007 Apr 30
Sitravatinib malate lib) Epub 2007 Apr 30Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1. 5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0. 5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib malate shows potent single agent antitumor efficacy and enhances the activity of PD 1 blockade through promoting an antitumor immune microenvironment. Product
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