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1038/s41598-017-00212-w
PER977 is a water-soluble
and 30 mg/kg
It binds to the Rad6B catalytic site
Chemical Name: 4-(2-(((6R
TAS-102 - CAS# 733030-01-8 Catalog No.:M6637-10S 1038/s41598-017-00212-wTAS 102, CAS No. 733030 01 8, is an investigational drug candidate for metastatic colorectal cancer. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 1; 0. 5. Trifluridine is a nucleoside analog, and tipiracil hydrochloride is a thymidine phosphorylase inhibitor, which prevents rapid metabolism of trifluiridine, increasing the bioavailability of trifluiridine. After oral administration of TAS 102, TFT is
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