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is a next-generation proteasome inhibitor with demonstrated preclinical and clinical antimyeloma activity
147(3):335-45
Smiles: O=C1NC(=O)C(=C1C1=CNC2=CC=CC=C21)C1=CNC2=CC=CC=C21
InChi: InChI=1S/C28H30F2N6O8S/c29-15-5-1-3-13(7-15)17-9-35(33-31-17)21-23(39)19(11-37)43-27(25(21)41)45-28-26(42)22(24(40)20(12-38)44-28)36-10-18(32-34-36)14-4-2-6-16(30)8-14/h1-10
In vivo: The upper dose level for once-daily administration of CFI-402257 is between 6 and 6
dBET6 - CAS# 1950634-92-0 23319 Ditrifluoroacetate is a next-generation proteasome inhibitordBET6, CAS No. 1950634 92 0, is a novel degrader of BET bromodomain proteins. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Product information CAS Number: 1950634 92 0 Molecular Weight: 841. 37 Formula: C42H45ClN8O7S Synonym: dBET6 d BET6 d BET6 Chemical Name: 2 ((S) 4 (4 Chlorophenyl) 2,3,9 trimethyl 6H thieno[3,2 f][1,2,4]triazolo[4,3 a][1,4]diazepin 6 yl) N (8 (2 ((2 (2,6 dioxopiperidin 3 yl) 1,3 dioxoisoindolin 4
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