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BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride
Cl-amidine TFA cyamine BAY 1895344 shows potent anti-tumorCl amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0. 8 M, 6. 2 M and 5. 9 M for PAD1, PAD3, and PAD4, respectively. Cl amidine TFA induces apoptosis in cancer cells. Cl amidine TFA induces microRNA (miR) 16 (miRNA 16, microRNA 16) expression and causes cell cycle arrest. Cl Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis
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