CHMFL-ABL-053 21061 including p53R175H

including p53R175H

OC1C=CC(=CC=1)N(C1C=CC=CC=1)C(=O)C1C=C(C2C=C3OCOC3=CC=2C(=O)N2CC3C=CC=CC=3C[C@H]2CN2CCOCC2)N2CCCCC2=1

Chemical Name: 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1

Chemical Name: N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}propanamide

with an IC50 of <3 nM for DNA-PK

CHMFL-ABL-053 21061 including p53R175HCHMFL ABL 053 (compound 18a) is a BCR ABL inhibitor with ABL1: IC50 of 70 nM. CHMFL ABL 053 is derived from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF 7). CHMFL ABL 053 inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG 01 (GI50 = 16 nM), through significant suppression of the BCR ABL auto phosphorylation (EC50 = 100 nM) and downstream mediators such as STAT5, Crkl and ERK's