A single Surgical Extraction isnt going to be too effective, so Id steer clear of this one outside of blue decks, but its a great option for them, especially because the harder graveyard hate messes with Snapcaster Mage
No opponent will gain life, but any other effects of that spell or ability will still happen
If you are aggressive, then getting something out of the way for a bit should give you that window to close the game
Thopter Depths Two major combos saw play for a while in formats like Extended with the Vampire Hexmage and Dark Depths combo (giving you a 20/20 indestructible, flying Marit Lage beater on the turn you played Vampire Hexmage) or the Sword of the Meek and Thopter Foundry combo engine that made a ton of 1/1 blue Thopters
Sacrifice after III.) I - The Ring tempts you, then each player mills cards equal to your Ring-bearer's power
Weirdly, setting up the Shift target Clarabelle Contented Wallflower makes the big Clara less likely to make a big impact