Tucking away even the largest threats buys multiple turns and sidesteps death triggers entirely, which is invaluable when answers are limited
The requirement of eight different names among unlocked doors translates to just four fully unlocked Room cards, which is a lot more attainable than it might first appear
Recurring this seems especially potent, with the first Rage ramping to make the second game-ending
Abrupt Decay Advent of the Wurm Aethermage's Touch Arid Mesa Basilisk Collar Blade Splicer Blood Moon Boros Reckoner Broodmate Dragon Cackling Counterpart Call of the Herd Cruel Ultimatum Cyclonic Rift Damnation Damping Matrix Deadeye Navigator Death's Shadow Desecration Demon Evil Twin Extractor Demon Falkenrath Aristocrat Fiery Justice Gifts Ungiven Goblin Guide Grafdigger's Cage Hellrider Marsh Flats Mind Shatter Misty Rainforest Mizzium Mortars Niv-Mizzet, Dracogenius Obzedat, Ghost Council Phantasmal Image Primal Command Pyromancer Ascension Ranger of Eos Restoration Angel Scalding Tarn Scavenging Ooze Sever the Bloodline Simic Sky Swallower Stoic Angel Stony Silence Summoning Trap Sance Terminus Thragtusk Ulvenwald Tracker Venser, Shaper Savant Verdant Catacombs Wort, the Raidmother Zealous Conscripts Zur the Enchanter
The distribution of different rarities has changed many times over the years, most recently with the 2024 Murders at Karlov Manor set
Facilier - Agent Provocateur and The Queen - Wicked and Vain, Id probably choose the inkable five-drop, favoring the card that can come down and provide value even earlier, but its really close and I would be happy to open either of them